Valproic Acid and Plasma Levels of Primidone and Derived Phenobarbital

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منابع مشابه

Valproic acid and plasma levels of primidone and derived phenobarbital.

Five patients were studied to determine whether kinetic interaction occurs between valproic acid and primidone. During concurrent administration of primidone and valproic acid no significant interaction was observed. Primidone and derived phenobarbital levels did not change significantly. No adjustment of primidone dose was required when valproic acid was used as adjunctive therapy.

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Clinical efficacy of valproic acid in relation to plasma levels.

Valproic acid is a new antiepileptic drug recently introduced in the United States for the treatment of absence seizures. In this study on patients with absence and other seizure types, the majority of patients achieved optimal control within four weeks of therapy. No patient responded to valproic acid who did not show an initial clinical response by four weeks of active therapy. Optimal respon...

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Plasma ammonia levels in patients treated with valproic acid

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Ammonia Blood Levels and Valproic Acid

The prevalence and magnitude of valproic acid (VPA)-related hyperammonemia (HA) were estimated by a review of the literature, and the clinical symptomatology and risk factors for the development of HA determined by researchers at university hospitals in Santiago, Chile; and Rush University Medical Center, Chicago, IL. Out of 183 studies between 1980 and 2005, 24 met inclusion criteria; 7 were p...

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ژورنال

عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

سال: 1981

ISSN: 0317-1671,2057-0155

DOI: 10.1017/s0317167100042931